Processing cord blood from premature infants into autologous red-blood-cell products for transfusion.
Vox Sang
; 100(4): 367-73, 2011 May.
Article
en En
| MEDLINE
| ID: mdl-21091698
ABSTRACT
BACKGROUND AND OBJECTIVES:
The use of umbilical cord blood (UCB) for transfusion purposes has gained interest the past years. UCB transfusion could serve premature infants, who often need transfusions early in life. MATERIAL ANDMETHODS:
We investigated the suitability of different storage media. UCB was collected after 25 0/7--35 6/7 gestational weeks and centrifuged to concentrate red cells subsequently stored in saline-adenine-glucose-mannitol (SAGM), or in additive solution-3 (AS-3), or stored as whole blood in citrate-phosphate-dextrose-adenine-1. Quality parameters were measured at 7 day intervals during 35 days and compared to the standard RBC product.RESULTS:
White-blood-cell- and platelet counts were higher in the UCB products. In the fractionated units, haemolysis remained below 1·0% in 64% after 14 days, and in 30% after 21 days. Storage in SAGM or AS-3 showed similar quality. Whole blood UCB showed better pH and haemolysis rates after 21 days.CONCLUSION:
UCB can be processed into autologous products for premature infants. Shelf-life is limited to 14-21 days and compares unfavourably to stored whole blood. Considering the early transfusion needs in these infants, a short shelf-life would not be a practical objection.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Eliminación de Componentes Sanguíneos
/
Conservación de la Sangre
/
Transfusión de Sangre Autóloga
/
Transfusión de Eritrocitos
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Sangre Fetal
Límite:
Female
/
Humans
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Male
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Newborn
Idioma:
En
Revista:
Vox Sang
Año:
2011
Tipo del documento:
Article
País de afiliación:
Países Bajos