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Aucubin modulates Bcl-2 family proteins expression and inhibits caspases cascade in H2O2-induced PC12 cells.
Xue, Hong Yu; Niu, Dong Yan; Gao, Gui Zhen; Lin, Qiu Ye; Jin, Li Ji; Xu, Yong Ping.
Afiliación
  • Xue HY; Department of Chemistry and Life Science, Suzhou University, No. 71 Bianhe Road, Suzhou, 234000 Anhui, People's Republic of China.
Mol Biol Rep ; 38(5): 3561-7, 2011 Jun.
Article en En | MEDLINE | ID: mdl-21120620
In this study, the effect of aucubin on H(2)O(2)-induced apoptosis was studied by using a rat pheochromocytoma (PC12) cell line. We have analyzed the apoptosis of H(2)O(2)-induced PC12 cells, H(2)O(2)-induced apoptosis appeared to correlate with lower Bcl-2 expression, higher Bax expression and sequential activation of caspase-3 leading to cleavage of poly-ADP-ribose polymerase (PARP). Aucubin not only inhibited lower Bcl-2 expression, high Bax expression, but also modulated caspase-3 activation, PARP cleavage, and eventually protected against H(2)O(2)-induced apoptosis. These results indicated that aucubin can obstruct H(2)O(2)-induced apoptosis by regulating of the expression of Bcl-2 and Bax, as well as suppression of caspases cascade activation.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Células PC12 / Apoptosis / Proteínas Proto-Oncogénicas c-bcl-2 / Caspasas / Glucósidos Iridoides / Peróxido de Hidrógeno Límite: Animals Idioma: En Revista: Mol Biol Rep Año: 2011 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Células PC12 / Apoptosis / Proteínas Proto-Oncogénicas c-bcl-2 / Caspasas / Glucósidos Iridoides / Peróxido de Hidrógeno Límite: Animals Idioma: En Revista: Mol Biol Rep Año: 2011 Tipo del documento: Article Pais de publicación: Países Bajos