Asymmetric total synthesis and structural elucidation of NFAT-68.

Wang, Lin; Xi, Yumeng; Yang, Shouliang; Zhu, Rong; Liang, Yufan; Chen, Jiahua; Yang, Zhen

Wang, Lin; Xi, Yumeng; Yang, Shouliang; Zhu, Rong; Liang, Yufan; Chen, Jiahua; Yang, Zhen.

Afiliación

Wang L; Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education and Beijing National Laboratory for Molecular Science (BNLMS), College of Chemistry, Peking University, Beijing 10087, China.

Org Lett ; 13(1): 74-7, 2011 Jan 07.

Article en En | MEDLINE | ID: mdl-21121639

ABSTRACT

ABSTRACT

Total synthesis of NFAT-68 (7) has been achieved and its relative stereochemistry has been determined. A key step thereof is the utilization of the chelation-controlled vinylogous Mukaiyama aldol reaction (VMAR) to stereoselectively synthesize the syn-aldol product 8. This developed chemistry is anticipated to have wider application in total syntheses of many other natural products.

Asunto(s)

Hidroquinonas/síntesis química; Cristalografía por Rayos X; Modelos Moleculares; Estructura Molecular; Estereoisomerismo

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hidroquinonas Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2011 Tipo del documento: Article País de afiliación: China

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google