[Rho GTPases as therapeutic targets in cancer and other human diseases]. / Rho GTPasas como blancos terapéuticos relevantes en cáncer y otras enfermedades humanas.
Medicina (B Aires)
; 70(6): 555-64, 2010.
Article
en Es
| MEDLINE
| ID: mdl-21163747
ABSTRACT
Rho GTPases are a key protein family controlling the transduction of external signals to cytoplasmatic and nuclear effectors. In the last few years, the development of genetic and pharmacological tools has allowed a more precise definition of the specific roles of Rho GTPases. The aim of this review is to describe the cellular functions regulated by these proteins with focus on the molecular mechanism involved. We also address the role of Rho GTPases in the development of different human diseases such as cancer. Finally, we describe different experimental therapeutic strategies with Rho GTPases as molecular targets.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Neurodegenerativas
/
Proteínas de Unión al GTP rho
/
Neoplasias
Límite:
Humans
Idioma:
Es
Revista:
Medicina (B Aires)
Año:
2010
Tipo del documento:
Article