Monitoring of motor disorders in 7-day-old rats with severe hypoxic-ischemic injury of the brain.
Bull Exp Biol Med
; 149(6): 677-81, 2010 Nov.
Article
en En
| MEDLINE
| ID: mdl-21165416
ABSTRACT
Seven-day old rats were subjected to unilateral ligation of the common carotid artery followed by 2-h exposure to a gas mixture consisting of 8% oxygen and 92% nitrogen. Locomotor function of rats was monitored weekly. Functional deficit in these animals persisted for at least 3 months. The exercise tests of rotarod, hanging, and narrowing track were most informative. Our results can be used in preclinical studies of new drugs for the therapy of perinatal brain injury.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hipoxia-Isquemia Encefálica
/
Trastornos del Movimiento
Límite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2010
Tipo del documento:
Article
País de afiliación:
Rusia