[Effects of stress on hippocampal Glu-NMDAR pathway in rats and mechanism of zinc protection].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
; 19(2): 161-4, 2003 May.
Article
en Zh
| MEDLINE
| ID: mdl-21207667
ABSTRACT
AIM:
To observe the effects of stress on Glu uptake and NMDAR of hippocampus synaptosome in rats with different zinc status.METHODS:
Stress model was established by photoelectric stimulus. The behaviors of rats were tested in open-field case. 3H-L-Glu was taken as radioligand to detect the NMDAR binding. Glu uptake was determined with radioimmunoassay.RESULTS:
Compared with CT rats, ZD rats performed less movement in open-field test, both Bmax of NMDAR and 3H-L-Glu uptake of hippocampus in these rats were significantly decreased. Compared with corresponding non-stressed groups, the stressed groups appeared longer latency and less movement in open-field test. Increased Bmax of NMDAR and decreased 3H-L-Glu uptake were observed in all stressed rats, but only in SZD rats these indices showed statistical difference.CONCLUSION:
Abnormal behaviors of rats induced by photoelectric stress were observed in open-field test, which was more serious in zinc deficiency rats. It is supposed that the Glu-NMDAR pathway is involved in the process of stress reaction. As it shows in our experiment, the changes of Bmax of NMDAR and 3H-L-Glu uptake of hippocampus synaptosome seems to be a part of the mechanisms of stress action.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Estrés Fisiológico
/
Zinc
/
Receptores de N-Metil-D-Aspartato
/
Hipocampo
Límite:
Animals
Idioma:
Zh
Revista:
Zhongguo Ying Yong Sheng Li Xue Za Zhi
Asunto de la revista:
FISIOLOGIA
Año:
2003
Tipo del documento:
Article
País de afiliación:
China