NMR applications for identifying ß-TrCP protein-ligand interactions.
Mini Rev Med Chem
; 11(4): 283-97, 2011 Apr.
Article
en En
| MEDLINE
| ID: mdl-21222584
ABSTRACT
In the absence of crystallographic data, NMR has emerged as the best way to define protein-ligand interactions. Using NMR experiments based on magnetization transfer, one can sort bound from unbound molecules, estimate the dissociation constant, identify contacts implied in the binding, characterize the structure of the bound ligand and conduct ligand competition assays.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas con Repetición de beta-Transducina
/
Ligandos
Límite:
Humans
Idioma:
En
Revista:
Mini Rev Med Chem
Asunto de la revista:
QUIMICA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Francia