[Effects of recombinant human erythropoietin on serum levels of neuron-specific enolase, S-100ß protein and myelin basic protein in rats following status epilepticus].
Zhongguo Dang Dai Er Ke Za Zhi
; 13(1): 50-2, 2011 Jan.
Article
en Zh
| MEDLINE
| ID: mdl-21251388
ABSTRACT
OBJECTIVE:
This study examined the effect of recombinant human erythropoietin (r-HuEPO) on the serum levels of neuron-specific enolase (NSE), S-100ß protein and myelin basic protein (MBP) in young rats 24 hrs after lithium-pilocarpine-induced status epilepticus (SE) in order to study the potential role of r-HuEPO in epileptic brain damage.METHODS:
Forty 19-21-day-old male Sprague-Dawley (SD) rats were randomly divided into four groups (n=10) normal control group, SE, r-HuEPO pretreated-SE and r-HuEPO. SE was induced by lithium-pilocarpine. R-HuEPO (500 IU/kg) was intraperitoneally injected in the r-HuEPO pretreated-SE and r-HuEPO groups 4 hrs before SE. Serum levels of NSE, S-100ß and MBP were determined 24 hrs after the SE event.RESULTS:
Serum levels of NSE, S-100ß and MBP in the SE group increased significantly compared with those in the normal control and the r-HuEPO groups (Pï¼0.05). The r-HuEPO pretreated-SE group showed significantly decreased serum levels of NSE, S-100ß and MBP compared with the SE group (Pï¼0.05).CONCLUSIONS:
r-HuEPO may reduce the expression of NSE, S-100ß and MBP and thus might provide an early protective effect against epileptic brain injury.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fosfopiruvato Hidratasa
/
Estado Epiléptico
/
Proteínas S100
/
Eritropoyetina
/
Proteína Básica de Mielina
/
Factores de Crecimiento Nervioso
Límite:
Animals
Idioma:
Zh
Revista:
Zhongguo Dang Dai Er Ke Za Zhi
Año:
2011
Tipo del documento:
Article
País de afiliación:
China