Coagulation factor VIII activity in diabetic patients.
Med Glas (Zenica)
; 8(1): 134-9, 2011 Feb.
Article
en En
| MEDLINE
| ID: mdl-21263411
ABSTRACT
AIM:
To examine coagulation factor VIII activity in plasma, as a risk factor for thrombosis, in the patients with diabetes mellitus (DM). Also, to assess its relationship with fibrinogen and fasting blood glucose concentrations and with body mass index.METHODS:
The plasma coagulation factor VIII activity, plasma levels of fibrinogen and blood glucose concentrations were measured in 30 patients with DM type 1, 30 patients with DM type 2 and in 30 healthy subjects. Body weight and body height were also measured and BMI was calculated.RESULTS:
The plasma factor VIII activity in patients with DM type 1 and patients with DM type 2 was significantly higher than the values measured in healthy subjects. There was no significant difference in the factor VIII activity between patients with DM type 1 and type 2. The concentrations of fibrinogen and blood glucose in both groups of patients were significantly higher than in the group of healthy subjects. Patients with DM type 2 had a significantly higher BMI compared to healthy subjects, as well as compared to patients with DM type 1. There was a significant positive correlation between plasma factor VIII activity and plasma level of fibrinogen and a significant negative correlation between factor VIII activity and BMI in patients with DM type 2.CONCLUSION:
Diabetic patients have the elevated plasma coagulation factor VIII activity and increased fibrinogen concentration thus an increased risk of thrombosis and vascular diseases.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Factor VIII
/
Diabetes Mellitus
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Med Glas (Zenica)
Asunto de la revista:
CIENCIAS DA NUTRICAO
/
MEDICINA
Año:
2011
Tipo del documento:
Article