Impact of 123I-FP-CIT (DaTSCAN) SPECT on the diagnosis and management of patients with dementia with Lewy bodies: a retrospective study.
Nucl Med Commun
; 32(4): 298-302, 2011 Apr.
Article
en En
| MEDLINE
| ID: mdl-21278615
ABSTRACT
OBJECTIVE:
To assess the impact of imaging the presynaptic dopaminergic terminal using DaTSCAN single-photon emission computed tomography (SPECT) on the clinical diagnosis and subsequent management of patients with possible dementia with Lewy bodies (DLB), who were referred for imaging.METHODS:
A retrospective case note study was undertaken, involving a series of consecutive patients who had undergone DaTSCAN SPECT 12-24 months earlier.RESULTS:
Case notes of 80 patients were reviewed. DaTSCAN imaging results were abnormal (indicating DLB) in 20 (25%) and normal (suggesting an alternative diagnosis or absence of disease) in 60 (75%) patients. Of the 20 patients with an abnormal scan, 18 had a postscan working clinical diagnosis of DLB (90%), one had diagnosis of vascular dementia (5%) and another had no recorded outcome (5%). Fifty-eight out of the 60 patients with a normal DaTSCAN image result had an alternative clinical diagnosis of DLB (95%). Consequently, DaTSCAN findings were concordant with the outcome clinical diagnosis in 76 out of the 80 (95%) cases. Subsequent to DaTSCAN SPECT, scan findings and diagnoses were discussed with patients and/or their carers in 94% of cases and subsequent treatment options discussed in 93% of cases.CONCLUSION:
It would seem that DaTSCAN imaging has a marked influence on the working clinical diagnosis and subsequent management of patients with suspected DLB.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tropanos
/
Tomografía Computarizada de Emisión de Fotón Único
/
Enfermedad por Cuerpos de Lewy
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Revista:
Nucl Med Commun
Año:
2011
Tipo del documento:
Article
País de afiliación:
Reino Unido