An adaptive nonparametric method in benchmark analysis for bioassay and environmental studies.
Stat Probab Lett
; 80(23-24): 1947-1953, 2010 Dec 01.
Article
en En
| MEDLINE
| ID: mdl-21278850
ABSTRACT
We present a novel nonparametric method for bioassay and benchmark analysis in risk assessment, which averages isotonic MLEs based on disjoint subgroups of dosages. The asymptotic theory for the methodology is derived, showing that the MISEs (mean integrated squared error) of the estimates of both the dose-response curve F and its inverse F(-1) achieve the optimal rate O(N(-4/5)). Also, we compute the asymptotic distribution of the estimate ζ~p of the effective dosage ζ(p) = F(-1) (p) which is shown to have an optimally small asymptotic variance.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Risk_factors_studies
Idioma:
En
Revista:
Stat Probab Lett
Año:
2010
Tipo del documento:
Article
País de afiliación:
Estados Unidos