An algorithm for genetic testing of frontotemporal lobar degeneration.
Neurology
; 76(5): 475-83, 2011 Feb 01.
Article
en En
| MEDLINE
| ID: mdl-21282594
ABSTRACT
OBJECTIVE:
To derive an algorithm for genetic testing of patients with frontotemporal lobar degeneration (FTLD).METHODS:
A literature search was performed to review the clinical and pathologic phenotypes and family history associated with each FTLD gene.RESULTS:
Based on the literature review, an algorithm was developed to allow clinicians to use the clinical and neuroimaging phenotypes of the patient and the family history and autopsy information to decide whether or not genetic testing is warranted, and if so, the order for appropriate tests.CONCLUSIONS:
Recent findings in genetics, pathology, and imaging allow clinicians to use the clinical presentation of the patient with FTLD to inform genetic testing decisions.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Algoritmos
/
Pruebas Genéticas
/
Predisposición Genética a la Enfermedad
/
Degeneración Lobar Frontotemporal
/
Proteínas del Tejido Nervioso
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Adult
/
Aged
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Neurology
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos