Methotrexate is highly potent against pyrimethamine-resistant Plasmodium vivax.
J Infect Dis
; 203(2): 207-10, 2011 Jan 15.
Article
en En
| MEDLINE
| ID: mdl-21288820
ABSTRACT
Resistance of vivax malaria to treatment with antifolates, such as pyrimethamine (Pyr), is spreading as mutations in the dihydrofolatereductase (dhfr) genes are selected and disseminated. We tested the antitumor drug methotrexate (MTX), a potent competitive inhibitor of dhfr, against 11 Plasmodium vivax isolates ex vivo, 10 of which had multiple dhfr mutations associated with Pyr resistance. Despite high-grade resistance to Pyr (median 50% inhibitory concentration [IC50], 13,345 nM), these parasites were all highly susceptible to MTX (median IC50, 2.6 nM). Given its potency against Pyr-resistant P. vivax, the antimalarial potential of MTX deserves further investigation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plasmodium vivax
/
Metotrexato
/
Antimaláricos
Límite:
Humans
Idioma:
En
Revista:
J Infect Dis
Año:
2011
Tipo del documento:
Article