Selective killing of tumor cells using EGF or TGF alpha-Pseudomonas exotoxin chimeric molecules.
Semin Cancer Biol
; 1(5): 345-50, 1990 Oct.
Article
en En
| MEDLINE
| ID: mdl-2129426
ABSTRACT
Many types of cancer cells display aberrantly high numbers of EGF receptors on their surface. We have targeted these cells for elimination by combining the cell binding ability of either epidermal growth factor or transforming growth factor type alpha with the potent cell killing activity of Pseudomonas exotoxin. These chimeric molecules are formed either by chemical conjugation of the two proteins or by expression of a gene fusion into a product containing both proteins. In this review, we show that these chimeric toxins are extremely cytotoxic to a variety of cancer cell lines.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inmunotoxinas
/
Exotoxinas
Límite:
Humans
Idioma:
En
Revista:
Semin Cancer Biol
Asunto de la revista:
NEOPLASIAS
Año:
1990
Tipo del documento:
Article