[Vasodilatory effects of CNP on aortic arteries of rabbits].
Sichuan Da Xue Xue Bao Yi Xue Ban
; 41(5): 767-70, 2010 Sep.
Article
en Zh
| MEDLINE
| ID: mdl-21302437
ABSTRACT
OBJECTIVE:
To investigate the mechanism of vasodilatory effects of C-type natriuretic peptide (CNP).METHODS:
Tension changes in aortic rings of rabbits were recorded with the presence of CNP or C-type natriuretic peptide receptor (NPR-C) agonist (cANF4-23) after pretreatment with epinephrine (NE) or 60 mmol/L KCl. The vasodilatory effects of four types of potassium channel blocker and NPR-C antagonist (cANF4-28) were also tested.RESULTS:
A maximal vasorelaxant effects of (33.5 +/- 5.9) % and (38.4 +/- 10.6)% were recorded in the presence of 1 micromol/L CNP and cANF4-23, respectively, cANF4-28 attenuated the action of CNP [(19.8 +/- 8.3)%]. The vasorelaxant effects of CNP and cANF4-23 decreased significantly after pretreatment with 60 mmol/L KCl (P < 0.01). Glibenclamide and BaCl2 also attenuated the relaxant activities of CNP (P < 0.05). But only BaClZ decreased the vasodilatory action of cANF4-23 (P < 0.05).CONCLUSION:
The relaxant activity of CNP is mediated through three paths NPR-B/KATP, NPR-C/KIR and NPR-C/calcium channels.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aorta Torácica
/
Vasodilatación
/
Vasodilatadores
/
Péptido Natriurético Tipo-C
Límite:
Animals
Idioma:
Zh
Revista:
Sichuan Da Xue Xue Bao Yi Xue Ban
Año:
2010
Tipo del documento:
Article
País de afiliación:
China