Subthalamic deep brain stimulation increases pallidal firing rate and regularity.
Exp Neurol
; 229(2): 517-21, 2011 Jun.
Article
en En
| MEDLINE
| ID: mdl-21303674
ABSTRACT
While high-frequency stimulation of the subthalamic nucleus (STN-HFS) is highly effective in the treatment of Parkinson's disease (PD), the mechanisms underlying its therapeutic action remain unclear. Here, we report changes of single-neuron pallidal activity during STN-HFS in a parkinsonian patient. STN-HFS increased firing rate in both segments of the pallidum. Neurons displayed time-locked responses to stimulation pulses, with an early excitation followed by inhibition and late excitation. Finally, pallidal neurons fired more regularly during STN-HFS. The time-locked responses and increased firing regularity may override abnormally patterned pallidal activity, and thereby significantly contribute to the clinical efficacy of STN-HFS in PD.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Núcleo Subtalámico
/
Estimulación Encefálica Profunda
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Globo Pálido
/
Neuronas
Límite:
Humans
Idioma:
En
Revista:
Exp Neurol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Alemania