Metabolic sequelae of ß-blocker therapy: weighing in on the obesity epidemic?
Int J Obes (Lond)
; 35(11): 1395-403, 2011 Nov.
Article
en En
| MEDLINE
| ID: mdl-21304487
ABSTRACT
BACKGROUND:
Sympathetic activation is an important metabolic adaptation limiting weight gain. Propensity of weight gain associated with ß-blocker therapy in the obese modern population is unknown.OBJECTIVE:
To determine whether chronic ß-blocker therapy reduces energy expenditure (EE) and increases body weight.METHODS:
We undertook (i) a mechanistic study comparing EE, diet-induced thermogenesis and habitual activity between healthy volunteers (n=11) with uncomplicated hypertension treated with a ß-blocker and anthropometrically matched controls (n=19) and (ii) three cross-sectional studies comparing body weight, body mass index (BMI) and waist circumference between ß-blocker treated and untreated patients from ambulatory patients attending (a) diabetes outpatient clinic (n=214), (b) hypertension outpatient (n=84) and (c) participants in a multi-centre type 2 diabetes trial (ADVANCE) (n=11140).RESULTS:
Among weight-matched ß-blocker users, diet-induced thermogenesis, fat oxidation rate and weekly habitual activity were lower by 50% (P<0.01), 32% (P=0.04) and 30% (P<0.01), respectively, compared with controls. In ß-blocker treated patients, the adjusted mean body weight was 9.2 ± 1.2 kg (P=0.0002) higher among those attending the diabetes clinic, 17.2 ± 3.2 kg (P=0.004) higher among those attending the hypertension clinic and 5.2 ± 0.7 kg (P=0.0003) higher at baseline among participants in the ADVANCE trial compared with patients not treated with ß-blockers. BMI displayed a similar difference.CONCLUSIONS:
EE is reduced and body weight increased in chronic ß-blocker users. We hypothesise that chronic ß-blockade causes obesity by blunting EE.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Peso Corporal
/
Antagonistas Adrenérgicos beta
/
Metabolismo Energético
/
Adiposidad
/
Antihipertensivos
/
Obesidad
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
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Male
/
Middle aged
País/Región como asunto:
Oceania
Idioma:
En
Revista:
Int J Obes (Lond)
Asunto de la revista:
METABOLISMO
Año:
2011
Tipo del documento:
Article
País de afiliación:
Australia