Production of anti-amyloid ß antibodies in mice fed rice expressing amyloid ß.
Biosci Biotechnol Biochem
; 75(2): 396-400, 2011.
Article
en En
| MEDLINE
| ID: mdl-21307566
ABSTRACT
The main signs of Alzheimer's disease (AD) are cognitive impairment and senile plaques composed of amyloid beta (Aß) observed in patients' brains. Therefore, therapy for AD focuses on the removal of Aß. We developed an "edible vaccine" that employs intestinal immunity with little to no side effects. Rice was utilized as an edible vaccine. It expressed GFP-Aß42. Aß rice was administered orally to wild-type (WT) mice causing production of anti-Aß antibodies. Since Aß rice was mixed with the cholera toxin B subunit (CTB), antibody against the rice seed protein was also produced. Then, mice were caused to develop immune tolerance against the rice seed protein by oral administration of Aß rice mixed with CTB. The results indicated that only anti-Aß antibodies were produced.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oryza
/
Péptidos beta-Amiloides
/
Vacunas Comestibles
/
Anticuerpos
Límite:
Animals
Idioma:
En
Revista:
Biosci Biotechnol Biochem
Asunto de la revista:
BIOQUIMICA
/
BIOTECNOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Japón