Bunodosine 391: an analgesic acylamino acid from the venom of the sea anemone Bunodosoma cangicum.
J Nat Prod
; 74(3): 378-82, 2011 Mar 25.
Article
en En
| MEDLINE
| ID: mdl-21309590
ABSTRACT
A new acylamino acid, bunodosine 391 (BDS 391), was isolated from the venom of the sea anemone Bunodosoma cangicum. The structure was elucidated by spectroscopic analyses (2D NMR, ESIMS/MS) and verified by its synthesis. Intraplantar injection of BDS 391 into the hind paw of a rat induced a potent analgesic effect. This effect was not altered by naloxone (an opioid receptor antagonist), but was completely reversed by methysergide (a serotonin receptor antagonist), indicating that the effect is mediated by activation of serotonin receptors.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Anémonas de Mar
/
Analgésicos
Límite:
Animals
Idioma:
En
Revista:
J Nat Prod
Año:
2011
Tipo del documento:
Article
País de afiliación:
Brasil