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Pharmacological blockade of 5-HT7 receptors as a putative fast acting antidepressant strategy.
Mnie-Filali, Ouissame; Faure, Céline; Lambás-Señas, Laura; El Mansari, Mostafa; Belblidia, Hassina; Gondard, Elise; Etiévant, Adeline; Scarna, Hélène; Didier, Anne; Berod, Anne; Blier, Pierre; Haddjeri, Nasser.
Afiliación
  • Mnie-Filali O; Université de Lyon, Université Claude Bernard Lyon 1, Faculty of Pharmacy, Laboratoire de Neuropharmacologie, CNRS EAC 5006, Lyon, France.
Neuropsychopharmacology ; 36(6): 1275-88, 2011 May.
Article en En | MEDLINE | ID: mdl-21326194
Current antidepressants still display unsatisfactory efficacy and a delayed onset of therapeutic action. Here we show that the pharmacological blockade of serotonin 7 (5-HT(7)) receptors produced a faster antidepressant-like response than the commonly prescribed antidepressant fluoxetine. In the rat, the selective 5-HT(7) receptor antagonist SB-269970 counteracted the anxiogenic-like effect of fluoxetine in the open field and exerted an antidepressant-like effect in the forced swim test. In vivo, 5-HT(7) receptors negatively regulate the firing activity of dorsal raphe 5-HT neurons and become desensitized after long-term administration of fluoxetine. In contrast with fluoxetine, a 1-week treatment with SB-269970 did not alter 5-HT firing activity but desensitized cell body 5-HT autoreceptors, enhanced the hippocampal cell proliferation, and counteracted the depressive-like behavior in olfactory bulbectomized rats. Finally, unlike fluoxetine, early-life administration of SB-269970, did not induce anxious/depressive-like behaviors in adulthood. Together, these findings indicate that the 5-HT(7) receptor antagonists may represent a new class of antidepressants with faster therapeutic action.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Antagonistas de la Serotonina / Sulfonamidas / Receptores de Serotonina / Trastorno Depresivo / Antidepresivos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neuropsychopharmacology Asunto de la revista: NEUROLOGIA / PSICOFARMACOLOGIA Año: 2011 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoles / Antagonistas de la Serotonina / Sulfonamidas / Receptores de Serotonina / Trastorno Depresivo / Antidepresivos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neuropsychopharmacology Asunto de la revista: NEUROLOGIA / PSICOFARMACOLOGIA Año: 2011 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido