ZBED6: The birth of a new transcription factor in the common ancestor of placental mammals.
Transcription
; 1(3): 144-148, 2010 Nov.
Article
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| MEDLINE
| ID: mdl-21326889
ABSTRACT
A DNA transposon integrated into -the genome of a primitive mammal some 200 million years ago and, millions of years later, it evolved an essential function in the common ancestor of all placental mammals. This protein, now named ZBED6, was recently discovered because a mutation disrupting one of its binding sites, in an intron of the IGF2 gene, makes pigs grow more muscle. These findings have revealed a new mechanism for regulating muscle growth as well as a novel transcription factor that appears to be of major importance for transcriptional regulation in placental mammals.
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MEDLINE
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En
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Transcription
Año:
2010
Tipo del documento:
Article
País de afiliación:
Suecia
Pais de publicación:
EEUU
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ESTADOS UNIDOS
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ESTADOS UNIDOS DA AMERICA
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EUA
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UNITED STATES
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UNITED STATES OF AMERICA
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US
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USA