Mapping of protein- and chromatin-interactions at the nuclear lamina.
Nucleus
; 1(6): 460-71, 2010.
Article
en En
| MEDLINE
| ID: mdl-21327087
ABSTRACT
The nuclear envelope and the lamina define the nuclear periphery and are implicated in many nuclear processes including chromatin organization, transcription and DNA replication. Mutations in lamin A proteins, major components of the lamina, interfere with these functions and cause a set of phenotypically diverse diseases referred to as laminopathies. The phenotypic diversity of laminopathies is thought to be the result of alterations in specific protein- and chromatin interactions due to lamin A mutations. Systematic identification of lamin A-protein and -chromatin interactions will be critical to uncover the molecular etiology of laminopathies. Here we summarize and critically discuss recent technology to analyze lamina-protein and-chromatin interactions.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Nucleares
/
Cromatina
/
Mapeo de Interacción de Proteínas
/
Lámina Nuclear
Límite:
Humans
Idioma:
En
Revista:
Nucleus
Año:
2010
Tipo del documento:
Article
País de afiliación:
Países Bajos