[Novel synthetic method and analgesic activity of tepoxalin].
Yao Xue Xue Bao
; 45(10): 1260-4, 2010 Oct.
Article
en Zh
| MEDLINE
| ID: mdl-21348304
ABSTRACT
Tepoxalin is a potent inhibitor of both the cyclooxygenase and lipoxygenase pathways of the arachidonic acid cascade, as well as a potent anti-inflammatory and control-pain (postoperation, arthritis et. al.) agent. The new method about the use of novel synthesis reagents and the first using ionic liquid as reactive solvent to synthesize tepoxalin were presented in this paper. The ionic liquid can be easily recycled and reused for several runs efficiently. The analgesic activity of tepoxalin was detected by acetic acid test on mice. The analysis of variance showed that oral administration of tepoxalin could significantly inhibit the number of writhing response within 1 hour and prolong the latent time in a dose dependent manner as compared with CMC control group (P < 0.05). At the same time, tepoxalin had the same analgesic activity as diclofenac sodium.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pirazoles
/
Dimensión del Dolor
/
Líquidos Iónicos
/
Analgésicos
Límite:
Animals
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Año:
2010
Tipo del documento:
Article
País de afiliación:
China