Population-based analysis of survival for hypoplastic left heart syndrome.
J Pediatr
; 159(1): 57-63, 2011 Jul.
Article
en En
| MEDLINE
| ID: mdl-21349542
ABSTRACT
OBJECTIVE:
To analyze survival patterns among infants with hypoplastic left heart syndrome (HLHS) in the State of Michigan. STUDYDESIGN:
Cases of HLHS prevalent at live birth were identified and confirmed within the Michigan Birth Defects Registry from 1992 to 2005 (n=406). Characteristics of infants with HLHS were compared with a 101 random control sample.RESULTS:
Compared with 4060 control subjects, the 406 cases of HLHS were more frequently male (62.6% vs 51.4%), born prematurely (<37 weeks gestation; 15.3% vs 8.7%), and born at low birth weight (LBW) (<2.5 kg; 16.0% vs 6.6%). HLHS 1-year survival rate improved over the study period (P=.041). Chromosomal abnormalities, LBW, premature birth, and living in a high poverty neighborhood were significantly associated with death. Controlling for neighborhood poverty, term infants versus preterm with HLHS or LBW were 3.2 times (95% CI 1.9-5.3; P<.001) more likely to survive at least 1 year. Controlling for age and weight, infants from low-poverty versus high-poverty areas were 1.8 times (95% CI 1.1-2.8; P=.015) more likely to survive at least 1 year.CONCLUSIONS:
Among infants with HLHS in Michigan, those who were premature, LBW, had chromosomal abnormalities, or lived in a high-poverty area were at increased risk for early death.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndrome del Corazón Izquierdo Hipoplásico
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspecto:
Determinantes_sociais_saude
Límite:
Female
/
Humans
/
Infant
/
Male
/
Newborn
País/Región como asunto:
America do norte
Idioma:
En
Revista:
J Pediatr
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos