[In vitro and in vivo anti-influenza virus activity of ribavirin injection].
Yao Xue Xue Bao
; 45(3): 403-7, 2010 Mar.
Article
en Zh
| MEDLINE
| ID: mdl-21351521
ABSTRACT
Ribavirin is a broad-spectrum inhibitor against several unrelated DNA or RNA viruses in vitro and in vivo. In this paper the in vitro and in vivo study of anti-influenza virus activity of ribavirin (RBV) injection had been reported. The in vitro antiviral activity of ribavirin injection against influenza virus A and B was studied by CPE. The in vivo protective action of ribavirin injection against influenza A/FM/1/47(H1N1) mouse adapted strain infected mouse was studied with mouse model. The results showed ribavirin injection has strong inhibitory activity against 7 virus strains tested in vitro. Ribavirin injection could significantly increase virus infected mouse survival rate and survival days and improve lung pathogen and lung index.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Ribavirina
/
Infecciones por Orthomyxoviridae
/
Subtipo H1N1 del Virus de la Influenza A
Límite:
Animals
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Año:
2010
Tipo del documento:
Article
País de afiliación:
China