[Concentrations of persistent organochlorine pesticides in whole blood of pregnant women in Hokkaido study on environment and children's health].
Nihon Eiseigaku Zasshi
; 66(1): 95-107, 2011 Jan.
Article
en Ja
| MEDLINE
| ID: mdl-21358140
ABSTRACT
OBJECTIVES:
This study was performed to evaluate the levels of exposure to persistent organochlorine pesticides in pregnant women in Hokkaido.METHODS:
Whole-blood samples were obtained from 70 pregnant women aged 17 to 39 years in Hokkaido and analyzed to quantify 29 organochlorine pesticides by gas chromatography/negative ion chemical ionization mass spectrometry and gas chromatography/high-resolution mass spectrometry.RESULTS:
Among 29 target compounds, 20 were detected in the whole-blood samples. Mirex, Parlar-26, and Parlar-50, which have never been used in Japan, were identified in all samples, as well as 11 compounds that have been used in Japan. Log-transformed concentrations of compounds with detection rates above 60% linearly correlated with each other (p<0.01). p,p'-DDE exhibited the highest concentration, with a geometric mean of 730 pg/g wet weight. From the results of the Jonckheere-Terpstra trend test, body weight or age was positively associated with the concentrations of several compounds.CONCLUSIONS:
We detected 22 organochlorine pesticides including pesticides with no history of use in Japan in the whole-blood samples from pregnant women in Hokkaido. Through long-distance transport mechanisms, these pollutants may distribute widely, and further surveillance of human blood, in addition to foods and the environment, should be conducted.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plaguicidas
/
Embarazo
/
Protección a la Infancia
/
Ambiente
/
Hidrocarburos Clorados
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
País/Región como asunto:
Asia
Idioma:
Ja
Revista:
Nihon Eiseigaku Zasshi
Año:
2011
Tipo del documento:
Article