[Immunogenetics of primary membranous glomerulonephritis]. / Immunogénétique des glomérulonéphrites extramembraneuses primitives.
Presse Med
; 19(21): 990-3, 1990 May 26.
Article
en Fr
| MEDLINE
| ID: mdl-2141152
ABSTRACT
In 65 patients with a biopsy-proven diagnosis of membranous glomerulonephritis, the association with HLA class I, class II and class III antigens was studied using classical techniques. We found a highly significant association with the HLA-DR3 (Pc = 8 x 10(-5)) antigen and with the HLA-B8 (Pc = 2 x 10(-4)) antigen in linkage disequilibrium with the former. In addition, there was an excess of null C4 allotypes (C4 AQo or C4 BQo) in patients and a significant decrease of BfS allele. Finally, the most commonly observed phenotype was A1 B8 DR3 BfS C4AQoB1. These results confirm a strong association between major histocompatibility complex and primary membranous glomerulonephritis, raising the possibility of a susceptibility gene being necessary for the development of that disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antígenos de Histocompatibilidad Clase I
/
Antígenos de Histocompatibilidad Clase II
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Glomerulonefritis
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Antígenos HLA
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Complejo Mayor de Histocompatibilidad
Límite:
Adult
/
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
Fr
Revista:
Presse Med
Año:
1990
Tipo del documento:
Article