Cholinergic dysfunction after traumatic brain injury: preliminary findings from a PET study.
Neurology
; 76(12): 1046-50, 2011 Mar 22.
Article
en En
| MEDLINE
| ID: mdl-21422456
ABSTRACT
OBJECTIVE:
There is evidence that the cholinergic system is frequently involved in the cognitive consequences of traumatic brain injury (TBI). We studied whether the brain cholinergic function is altered after TBI in vivo using PET.METHODS:
Cholinergic function was assessed with [methyl-(11)C]N-methylpiperidyl-4-acetate, which reflects the acetylcholinesterase (AChE) activity, in 17 subjects more than 1 year after a TBI and in 12 healthy controls. All subjects had been without any centrally acting drugs for at least 4 weeks.RESULTS:
The AChE activity was significantly lower in subjects with TBI compared to controls in several areas of the neocortex (-5.9% to -10.8%, p=0.053 to 0.004).CONCLUSIONS:
Patients with chronic cognitive symptoms after TBI show widely lowered AChE activity across the neocortex.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Acetilcolinesterasa
/
Encéfalo
/
Lesiones Encefálicas
/
Trastornos del Conocimiento
/
Tomografía de Emisión de Positrones
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Neurology
Año:
2011
Tipo del documento:
Article
País de afiliación:
Finlandia