Adaptive radiotherapy in muscle invasive urinary bladder cancer--an effective method to reduce the irradiated bowel volume.
Radiother Oncol
; 99(1): 61-6, 2011 Apr.
Article
en En
| MEDLINE
| ID: mdl-21429607
ABSTRACT
BACKGROUND AND PURPOSE:
To evaluate the benefits of adaptive radiotherapy for bladder cancer in decreasing irradiation of small bowel. MATERIAL ANDMETHODS:
Five patients with muscle invasive bladder cancer received adaptive radiotherapy to a total dose of 55.8-65 Gy with daily cone-beam computed tomography scanning. The whole bladder was treated to 45-50.4 Gy, followed by a partial bladder boost. The plan of the day was chosen from 3 to 4 pre-planned treatment plans according to the visible extent of bladder wall in cone-beam computed tomography images. Dose volume histograms for intestinal cavity volumes were constructed and compared with corresponding histograms calculated for conventional non-adaptive radiotherapy with single treatment plan of 2 cm CTV-PTV margins. CTV dose coverage in adaptive treatment technique was compared with CTV dose coverage in conventional radiotherapy.RESULTS:
The average volume of intestinal cavity receiving ≥ 45 Gy was reduced from 335 ± 106 cm(3) to 180 ± 113 cm(3) (1SD). The maximum volume of intestinal cavity spared at 45 Gy on a single patient was 240 cm(3), while the minimum volume was 65 cm(3). The corresponding reduction in average intestinal cavity volume receiving ≥ 45 Gy calculated for the whole bladder treatment only was 66 ± 36 cm(3). CTV dose coverage was improved on two out of five patients and decreased on three patients.CONCLUSIONS:
Adaptive radiotherapy considerably reduces dose to the small bowel, while maintaining the dose coverage of CTV at similar level when compared to the conventional treatment technique.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias de la Vejiga Urinaria
/
Planificación de la Radioterapia Asistida por Computador
/
Intestino Delgado
Límite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Radiother Oncol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Finlandia