Use of intravenous etomidate to control acute psychosis induced by the hypercortisolaemia in severe paediatric Cushing's disease.
Horm Res Paediatr
; 75(6): 441-6, 2011.
Article
en En
| MEDLINE
| ID: mdl-21430362
ABSTRACT
BACKGROUND:
Psychosis secondary to paediatric Cushing's disease (CD) is extremely rare and presents a significant management challenge.METHOD:
We report a 14.7-year-old CD patient with acute psychosis and self-inflicted injuries following failed transsphenoidal pituitary surgery. Her mental state rapidly deteriorated precluding medical therapy.RESULTS:
Emergency intravenous low-dose etomidate infusion (3-3.5 mg/h) with dose titration according to the serum cortisol combined with a hydrocortisone infusion, in an intensive care setting, was effective in controlling the hypercortisolaemia. Her mental state improved with normalisation of her cortisol levels enabling oral administration of ketoconazole and bilateral adrenalectomy to be performed.CONCLUSION:
This case illustrates the safe and effective use of a low-dose etomidate infusion in an unusual case of paediatric CD.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastornos Psicóticos
/
Anestésicos Intravenosos
/
Síndrome de Cushing
/
Hipersecreción de la Hormona Adrenocorticotrópica Pituitaria (HACT)
/
Etomidato
Tipo de estudio:
Etiology_studies
Límite:
Adolescent
/
Female
/
Humans
Idioma:
En
Revista:
Horm Res Paediatr
Asunto de la revista:
ENDOCRINOLOGIA
/
PEDIATRIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Reino Unido