New treatment of free-radical scavenger in adrenoleukodystrophy.
J Clin Pharm Ther
; 36(3): 412-5, 2011 Jun.
Article
en En
| MEDLINE
| ID: mdl-21463348
ABSTRACT
WHAT IS KNOWN AND OBJECTIVE:
Adrenoleukodystrophy (ALD) is an X-linked disorder and characterized by the accumulation of saturated very long-chain fatty acids. Treatment is still unsatisfactory. Our objective is to report on the effect of the free-radical scavenger, edaravone, in a patient with ALD. CASESUMMARY:
The patient was given edaravone intravenously twice. D-ROM in cerebral spinal fluid decreased dramatically, and a shortening of neuronal transmission time as estimated on somatosensory evoked potential was observed. After terminating the treatment, his symptoms progressively reappeared. WHAT IS NEW ANDCONCLUSION:
This is the first report of the use of edaravone in ALD. The drug is apparently effective in improving symptoms of ALD and should be evaluated more formally.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antipirina
/
Depuradores de Radicales Libres
/
Adrenoleucodistrofia
Límite:
Child
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Pharm Ther
Asunto de la revista:
FARMACIA
/
TERAPEUTICA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Japón