Why the histocompatibility system exists and how transplant surgeons can xenograft without rejection.
QJM
; 104(9): 767-9, 2011 Sep.
Article
en En
| MEDLINE
| ID: mdl-21467153
ABSTRACT
The histocompatibility system is responsible for the rejection of allografts. The system exists to counter the explosive speed of viral replication by directing the defensive immune attack by cytotoxic T cells on to histocompatibility antigens on the infected cell's surface. This enables destruction of the virus factories before the cytotoxic T cells are swamped by the myriad numbers of new virions, a thousand coming from each infected cell every 10 h. The immunity system mistakes alloantigens for virus-infected host cells that need swift destruction. For transplantation, Sykes has improved Kaplan's technique by adding recipient bone marrow cells to the donor ones injected for reconstitution of the recipient after immune ablation. This technique should enable the use of xenografts from pigs.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trasplante Heterólogo
/
Histocompatibilidad
Límite:
Animals
/
Humans
Idioma:
En
Revista:
QJM
Asunto de la revista:
MEDICINA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Nueva Zelanda
Pais de publicación:
ENGLAND
/
ESCOCIA
/
GB
/
GREAT BRITAIN
/
INGLATERRA
/
REINO UNIDO
/
SCOTLAND
/
UK
/
UNITED KINGDOM