Immuno-potentiating role of encapsulated proteins of infectious diseases in biopolymeric nanoparticles as a potential delivery system.
J Biomed Nanotechnol
; 7(1): 63-4, 2011 Feb.
Article
en En
| MEDLINE
| ID: mdl-21485804
ABSTRACT
The study aimed to evaluate encapsulation of therapeutic proteins in nanoparticles to understand the interactions among Cytokines in the immune response to chronic infection, induction of long lasting memory cell formation and cytokine production. Chitosan nanoparticles in the size range of approximately 200 nm were prepared by ionic gelation method which binds with M. tuberculosis CFP-10 and CFP-21 proteins. Mean Residence Time were found to be higher for nanoparticles coated CFP-10 and CFP-21 proteins resulting in increase in relative bioavailability of encapsulated proteins in comparison with free proteins. Proteins encapsulated nanoparticles exerted negligible cytotoxicity as compared to 80% cytotoxicity by CFP-10 and CFP-21 proteins per se.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Nanocápsulas
/
Inmunidad Innata
/
Melanoma
Aspecto:
Implementation_research
Límite:
Animals
Idioma:
En
Revista:
J Biomed Nanotechnol
Año:
2011
Tipo del documento:
Article
País de afiliación:
India