Changes in muscle T2 and tissue damage after downhill running in mdx mice.
Muscle Nerve
; 43(6): 878-86, 2011 Jun.
Article
en En
| MEDLINE
| ID: mdl-21488051
ABSTRACT
INTRODUCTION:
In this study we compared the effects of downhill or horizontal treadmill running on the magnetic resonance imaging (MRI) transverse relaxation time constant (T(2)) in mdx mice.METHODS:
Mice underwent either downhill (n = 11 mdx, n = 6 controls) or horizontal running (n = 9, mdx only) on a treadmill. MRI was conducted prior to exercise, immediately afterward (â½20 minutes), and then 24 and 48 hours after exercise.RESULTS:
A higher percentage of pixels with elevated T(2) in the lower hindlimb muscles was observed in the mdx mice compared with controls both pre-exercise (P < 0.001) and at each time-point after downhill running (P < 0.05), but not with horizontal running. The medial compartment muscles appeared to be the most susceptible to increased T(2).CONCLUSIONS:
Downhill running provides a stimulus for inducing acute changes in muscle T(2) in mdx mice. MRI is a non-invasive approach for examining acute muscle damage and recovery in multiple muscle groups simultaneously.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carrera
/
Músculo Esquelético
/
Traumatismos de la Pierna
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Muscle Nerve
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos