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Activation of coagulation in amniotic fluid during normal human pregnancy.
Sarig, Galit; Klil-Drori, Adi J; Chap-Marshak, Dafna; Brenner, Benjamin; Drugan, Arieh.
Afiliación
  • Sarig G; Hematology Laboratory, Rambam Health Care Campus and the Bruce Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, Israel. g_sarig@rambam.health.gov.il
Thromb Res ; 128(5): 490-5, 2011 Nov.
Article en En | MEDLINE | ID: mdl-21504838
INTRODUCTION: Amniotic fluid (AF) is an important medium for fetal development which exhibits high procoagulant activities; however, the role of these procoagulants during pregnancy has not been elucidated and might be associated with pregnancy complications. The current study aimed to evaluate factor X (FX) activation and its association with tissue factor (TF), tissue factor pathway inhibitor (TFPI) and coagulation activation markers in AF during normal human pregnancy. METHODS: Activation of FX and concentration of TF, free TFPI, D-dimer and prothrombin fragments (F1+2) were evaluated in AF samples obtained for chromosome analysis from 91 women with normal pregnancy: 65 samples were taken from patients at 16-20 weeks of gestation, 9 samples were drawn at 21-30 weeks and 17 samples--after 30 weeks of gestation. RESULTS: Activation of FX in AF significantly increased during normal pregnancy (from 65±41 to 205±80 equivalent RVV ng/mg total protein, P<0.0001). TF and TFPI levels in AF also rose with gestational age. In contrast, the AF concentration of D-dimer and F1+2, markers of coagulation activation significantly decreased when expressed per mg total protein. Levels of free TFPI correlated with TF (r=0.5, P<0.001), and were 8-fold higher than those of TF during pregnancy. CONCLUSION: High levels of TFPI might be associated with the inhibition of procoagulant activity in amniotic fluid during normal pregnancy, which may account for the rarity of clinical amniotic fluid embolism.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Coagulación Sanguínea / Embolia de Líquido Amniótico / Líquido Amniótico Tipo de estudio: Etiology_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Thromb Res Año: 2011 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Coagulación Sanguínea / Embolia de Líquido Amniótico / Líquido Amniótico Tipo de estudio: Etiology_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Thromb Res Año: 2011 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos