Metabolic studies on the hypolipidaemic effect of guar gum.
Atherosclerosis
; 81(2): 145-50, 1990 Mar.
Article
en En
| MEDLINE
| ID: mdl-2157450
ABSTRACT
The hypolipidaemic effect of guar gum (30 g/day) was examined in a double blind placebo-controlled crossover study in 9 patients with primary hyperlipidaemia. The treatment periods were of six weeks duration. Cholesterol levels in low density lipoprotein (LDL) were decreased by 11.5% and in intermediate density lipoprotein (IDL) by 10.7%. Plasma cholesterol levels were reduced by 9.6% (P less than 0.05). Kinetic studies using autologous 125I-labelled LDL showed a decrease of 21.6% in plasma LDL apo B pool size (P less than 0.05) that resulted from a 39.1% increase in its fractional rate of catabolism. The kinetic effects of guar gum on LDL metabolism appear similar to that of bile acid binding resins in that LDL apo B fractional catabolism is greatly increased while there is a slight increase in production rate.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fibras de la Dieta
/
Galactanos
/
Hipobetalipoproteinemias
/
Hipolipoproteinemias
/
Lipoproteínas LDL
/
Mananos
Tipo de estudio:
Clinical_trials
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Atherosclerosis
Año:
1990
Tipo del documento:
Article
País de afiliación:
Reino Unido