Safety of antibiotic drugs in food animals: comparison of findings from preapproval studies and postapproval experience in the United States with safety information in published literature.
Vet Clin North Am Food Anim Pract
; 27(2): 389-405, ix, 2011 Jul.
Article
en En
| MEDLINE
| ID: mdl-21575776
ABSTRACT
Antibiotics are among the most widely prescribed drugs and are generally considered safe for the target species. However, their use has been associated with various adverse toxic effects in target animals, such as allergic reactions, gastrointestinal signs, cardiovascular effects, hypoglycemia, hepatic/renal toxicity, thrombocytopenia, and anaphylaxis. This article provides a qualitative summary of the adverse events observed in target animals during the evaluation of antibiotics by the Food and Drug Administration during both preapproval and postapproval periods. As there is a marked scarcity of published data on safety of antibiotics in food animals, more research is needed in this area.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vigilancia de Productos Comercializados
/
Ensayos Clínicos como Asunto
/
Aprobación de Drogas
/
Enfermedades de los Animales
/
Antibacterianos
Tipo de estudio:
Diagnostic_studies
/
Qualitative_research
Límite:
Animals
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Vet Clin North Am Food Anim Pract
Asunto de la revista:
MEDICINA VETERINARIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos