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Extracellular histone induces plasma hyaluronan-binding protein (factor VII activating protease) activation in vivo.
Yamamichi, Shingo; Fujiwara, Yukari; Kikuchi, Tadashi; Nishitani, Miki; Matsushita, Yasuhiko; Hasumi, Keiji.
Afiliación
  • Yamamichi S; Department of Applied Biological Science, Tokyo Noko University, 3-5-8 Saiwaicho, Fuchu, Tokyo 183-8509, Japan.
Biochem Biophys Res Commun ; 409(3): 483-8, 2011 Jun 10.
Article en En | MEDLINE | ID: mdl-21600885
Plasma hyaluronan-binding protein (PHBP), an activator of factor VII and prourokinase, is a serine protease circulating as a single-chain proenzyme (pro-PHBP). Pro-PHBP converts to the active two-chain form through autoproteolysis, and effectors that modulate autoactivation can regulate PHBP-mediated processes. Here, we show that histone promotes pro-PHBP autoactivation in vivo. Histone bound to pro-PHBP and promoted intermolecular pro-PHBP binding. Histone-mediated pro-PHBP activation in plasma leads to the formations of bradykinin and PHBP-α(2)-antiplasmin complex as well as histone degradation. Pro-PHBP activation was observed in the circulation of mice after injection of histone or lipopolysaccharide, which induced septic response accompanying extracellular histone release. Our results suggest pathophysiological relevance of histone-dependent pro-PHBP activation in hyperinflammatory process.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serina Endopeptidasas / Histonas / Inflamación Límite: Animals / Female / Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2011 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serina Endopeptidasas / Histonas / Inflamación Límite: Animals / Female / Humans Idioma: En Revista: Biochem Biophys Res Commun Año: 2011 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos