The effects of orally administered delta 9-tetrahydrocannabinol in man on mood and performance measures: a dose-response study.
Pharmacol Biochem Behav
; 35(4): 861-4, 1990 Apr.
Article
en En
| MEDLINE
| ID: mdl-2161109
ABSTRACT
A dose-response study of the effect of orally administered delta 9-tetrahydrocannabinol (THC) on human mood and skills performance was conducted. Using five dose levels of THC (0, 5, 10, 15, 20 mg) with 16 volunteers per dosage group, mood and performance measures were recorded at five testing occasions, one before and four after drug administration. The slope of the linear regression of performance on the test battery was significant for up to 200 minutes after dosage. That is to say, oral THC, at the doses used, produced significant dose-dependent impairment of performance for a period in excess of three hours. A similar time course for the effect of THC on the subjective assessment of intoxication ('stone') suggested a correlation between drug-induced impairment skills and the effects on mood.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Desempeño Psicomotor
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Dronabinol
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Afecto
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Pharmacol Biochem Behav
Año:
1990
Tipo del documento:
Article
Pais de publicación:
EEUU
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ESTADOS UNIDOS
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ESTADOS UNIDOS DA AMERICA
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EUA
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UNITED STATES
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UNITED STATES OF AMERICA
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US
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USA