Lipin-1γ isoform is a novel lipid droplet-associated protein highly expressed in the brain.
FEBS Lett
; 585(12): 1979-84, 2011 Jun 23.
Article
en En
| MEDLINE
| ID: mdl-21616074
ABSTRACT
Lipin-1 proteins are phosphatidic acid phosphatases (PAPs) catalyzing the conversion from phosphatidic acid (PA) to diacylglycerol (DG). Two alternative splicing isoforms, lipin-1α and -1ß, are localized at different subcellular compartments. A third splicing isoform, lipin-1γ was recently cloned and its subcellular localization is unknown. Here, we demonstrate that lipin-1γ is localized to lipid droplets (LDs), an association mediated by a hydrophobic, lipin-1γ-specific domain. Additional expression of lipin-1γ altered LD morphology without affecting the triacylglycerol (TG) level. In human tissues, lipin-1γ is the main lipin-1 isoform expressed in normal human brain, suggesting a specialized role in regulating brain lipid metabolism.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
/
Proteínas Nucleares
/
Metabolismo de los Lípidos
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
FEBS Lett
Año:
2011
Tipo del documento:
Article
País de afiliación:
Canadá