Overexpression of the TXNDC5 protein in non-small cell lung carcinoma.
Anticancer Res
; 31(5): 1577-82, 2011 May.
Article
en En
| MEDLINE
| ID: mdl-21617212
ABSTRACT
UNLABELLED Thioredoxin domain containing protein 5 (TXNDC5) is a member of the thioredoxin (Trx) domain-containing family of proteins that have been implicated in cancer progression. The expression of TXNDC5 in non-small cell lung carcinoma (NSCLC) tumours compared to patient-matched normal lung tissue was determined and cell line models were used to determine if expression was regulated by hypoxia. PATIENTS AND METHODS:
Samples of tumour and normal lung tissue were taken during surgery and immediately frozen. The expression of TXNDC5 was determined by Western blotting and immunohistochemistry. To analyse the effect of hypoxia on TXNDC5 expression NSCLC cell lines were used.RESULTS:
Tumours from 18/29 (62%) individuals exhibited an increase in TXNDC5 expression compared to normal lung tissue (p<0.05). TXNDC5 expression was not elevated by hypoxia.CONCLUSION:
TXNDC5 is up-regulated in the majority of resected human NSCLC. Cell line data indicates that the expression of TXNDC5 in tumour cells is not regulated by hypoxia.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carcinoma de Células Escamosas
/
Adenocarcinoma
/
Carcinoma de Pulmón de Células no Pequeñas
/
Adenocarcinoma Bronquioloalveolar
/
Proteína Disulfuro Isomerasas
/
Pulmón
/
Neoplasias Pulmonares
Tipo de estudio:
Observational_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Anticancer Res
Año:
2011
Tipo del documento:
Article
País de afiliación:
Reino Unido
Pais de publicación:
GR
/
GRECIA
/
GREECE
/
GRÉCIA