The tumor necrosis factor-related apoptosis-inducing ligand and lung cancer: still following the right TRAIL?
J Thorac Oncol
; 6(6): 983-7, 2011 Jun.
Article
en En
| MEDLINE
| ID: mdl-21623278
ABSTRACT
Tumor necrosis factor-related apoptosis-inducing ligand is a type II membrane-bound protein whose C-terminal extracellular domain shows clear homology to other tumor necrosis factor family members. It is constitutively expressed on macrophages, T cells, natural killer cells, and dendritic cells and selectively kills transformed cells leaving most of the normal cells alone. This selectivity has led to great interest in it use as a therapeutic agent for the treatment of malignancy. In this review, this critical pathway is described, highlighting its mechanistic manipulation for therapeutic benefit and the recent phase I and II trials in lung cancer that have been performed or are currently ongoing are also discussed.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Ligando Inductor de Apoptosis Relacionado con TNF
/
Neoplasias Pulmonares
/
Proteínas de Neoplasias
Tipo de estudio:
Guideline
Límite:
Humans
Idioma:
En
Revista:
J Thorac Oncol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Reino Unido