Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase.
Bioorg Med Chem Lett
; 21(13): 4066-71, 2011 Jul 01.
Article
en En
| MEDLINE
| ID: mdl-21641211
ABSTRACT
The synthesis and SAR studies of a novel N-aryl pyridinone class of p38 kinase inhibitors are described. Systematic structural modifications to the HTS lead, 5, led to the identification of (-)-4a as a clinical candidate for the treatment of inflammatory diseases. Additionally, the chiral synthesis and properties of (-)-4a are described.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pironas
/
Benzamidas
/
Proteínas Quinasas p38 Activadas por Mitógenos
/
Inhibidores Enzimáticos
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos