In PSC with colitis treated with UDCA, most colonic carcinomas develop in the first years after the start of treatment.
Dig Dis Sci
; 56(12): 3624-30, 2011 Dec.
Article
en En
| MEDLINE
| ID: mdl-21656181
ABSTRACT
BACKGROUND:
Patients with PSC and IBD have a high incidence of colonic carcinomas (CRC), and the annual incidence of CRC increases with duration of disease. UDCA treatment has been suggested to reduce colonic dysplasias and carcinomas.AIMS:
The annual incidence of colorectal carcinomas after long-term UDCA treatment was studied.METHODS:
Patients included in a prospective study on the outcome after ursodeoxycholic acid (UDCA) treatment were evaluated.RESULTS:
A total of 120 of 171 PSC patients included had IBD (108 UC and 12 CD). All patients were treated with UDCA for a median time of 6.7 years. Seven patients with PSC and IBD developed a CRC yielding a prevalence of 5.8%. In years 0-3 (n = 120) after the start of UDCA, the annual incidence rate of CRC was 0.62/100 patient years; in years 3-6 (n = 93) it increased to 1.28 and decreased thereafter in years 6-9 (n = 67) to 1.17, then in years 9-12 (n = 42) to 0 and after >12 years (n = 24) it remained 0. In PSC with IBD, Kaplan-Meier estimate of CRC formation increased with time in the first years of treatment and reached a plateau after 9 years; after treatment for ≥ 9 years, no further CRC were observed.CONCLUSION:
After the start of UDCA, the annual incidence of CRC increased up to 6 years and subsequently decreased. In PSC with IBD treated with UDCA, most colonic carcinomas develop in the first years after the start of treatment.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácido Ursodesoxicólico
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Colangitis Esclerosante
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Neoplasias Colorrectales
Tipo de estudio:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Child
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Female
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Humans
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Male
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Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Dig Dis Sci
Año:
2011
Tipo del documento:
Article
País de afiliación:
Alemania