The molecular pathology of respiratory-chain dysfunction in human mitochondrial myopathies.
Biochim Biophys Acta
; 1018(2-3): 217-22, 1990 Jul 25.
Article
en En
| MEDLINE
| ID: mdl-2168209
ABSTRACT
Some of the different molecular pathologies of respiratory-chain dysfunction in human mitochondrial myopathies will be reviewed in relation to the findings in 58 cases. Deletions of mitochondrial DNA were identified in 21 cases [36%]. There was some correlation between the sites of the deletion and the mitochondrial biochemistry in patients with defects of Complex I but not in cases with more extensive loss of respiratory chain activity. Complex I and Complex IV polypeptides were usually normal in deleted cases. Non-deleted cases, however, often showed specific subunit deficiencies which involved the products of both nuclear and mitochondrial genes. Immunoblots of respiratory-chain polypeptides in one case pointed to defective translocation of the Rieske precursor from the cytosol into the mitochondria. The pathogenic role of circulating autoantibodies to specific matrix proteins and the nature of the target antigens in two patients with mitochondrial encephalomyopathies and respiratory-chain dysfunction will also be discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quinona Reductasas
/
Complejo IV de Transporte de Electrones
/
Complejo III de Transporte de Electrones
/
Mitocondrias Musculares
/
Enfermedades Musculares
Tipo de estudio:
Prognostic_studies
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Biochim Biophys Acta
Año:
1990
Tipo del documento:
Article
País de afiliación:
Reino Unido