[Is xanthine oxidase a universal source of superoxide radicals in ischemic and reperfusion lesions?]. / Iavliaetsia li ksantinoksidaza universal'nym istochnikom superoksidnykhradikalov pri ishemicheskom i reperfuzionnom povrezhdeniiakh?

ABSTRACT

While studying xanthine-xanthine oxidase system it was found, that a considerable accumulation of xanthine and uric acid occurred whereas xanthine dehydrogenase did not transfer in xanthine oxidase during 2 hours of total rat liver ischemia. These data make it possible to reject the generally accepted hypothesis of xanthine oxidase key role in free radical mechanism of ischemia damage.