Net oxidative addition of C(sp3)-F bonds to iridium via initial C-H bond activation.
Science
; 332(6037): 1545-8, 2011 Jun 24.
Article
en En
| MEDLINE
| ID: mdl-21700870
ABSTRACT
Carbon-fluorine bonds are the strongest known single bonds to carbon and as a consequence can prove very hard to cleave. Alhough vinyl and aryl C-F bonds can undergo oxidative addition to transition metal complexes, this reaction has appeared inoperable with aliphatic substrates. We report the addition of C(sp(3))-F bonds (including alkyl-F) to an iridium center via the initial, reversible cleavage of a C-H bond. These results suggest a distinct strategy for the development of catalysts and promoters to make and break C-F bonds, which are of strong interest in the context of both pharmaceutical and environmental chemistry.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carbono
/
Flúor
/
Hidrógeno
Idioma:
En
Revista:
Science
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos