Antibody responses to the immunodominant Cryptosporidium gp15 antigen and gp15 polymorphisms in a case-control study of cryptosporidiosis in children in Bangladesh.
Am J Trop Med Hyg
; 85(1): 97-104, 2011 Jul.
Article
en En
| MEDLINE
| ID: mdl-21734132
ABSTRACT
Although Cryptospridium hominis is the dominant Cryptosporidium species infecting humans, immune responses to cognate antigens in C. hominis-infected persons have not been reported. We investigated antibody responses to the immunodominant gp15 antigen from C. hominis and C. parvum, in C. hominis-infected Bangladeshi children less than five years of age with diarrhea (cases) and uninfected children with diarrhea (controls). We also investigated polymorphisms in the C. hominis gp15 sequence from cases. Serum IgG responses to gp15 from both species were significantly greater in cases than controls. In spite of polymorphisms in the gp15 sequence, there was a significant correlation between antibody levels to gp15 from both species, indicating cross-reactivity to conserved epitopes. Cases with acute diarrhea had a significantly greater serum IgA response to gp15 compared with those with persistent diarrhea, suggesting that this response may be associated with protection from prolonged disease. These findings support further investigation of gp15 as a vaccine candidate.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
/
Anticuerpos Antiprotozoarios
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Criptosporidiosis
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Cryptosporidium
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Diarrea
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Antígenos de Protozoos
Tipo de estudio:
Observational_studies
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Risk_factors_studies
Límite:
Animals
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Child, preschool
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Humans
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Infant
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Newborn
País/Región como asunto:
Asia
Idioma:
En
Revista:
Am J Trop Med Hyg
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos