Prediction of mortality in patients with major burns: clinical and biochemical factors.
Ann Plast Surg
; 67(3): 226-31, 2011 Sep.
Article
en En
| MEDLINE
| ID: mdl-21734539
ABSTRACT
OBJECTIVE:
The plasma electric charge, in addition to clinical factors, was considered to improve the prediction of mortality in patients with major burns.METHODS:
A software called PICAL 5.0 was used to determinate the plasma electric charge in 143 patients with major burns from the intensive care burn unit-Unfallkrankenhaus Berlin (Germany). In addition, a retrospective study with these patients was developed involving (1) biochemical variables in the first 48 hours pH value, [albumin], [Ca(2+)], etc; (2) clinical aspects age, total body surface area and full-thickness surface area burned, diagnosis of inhalation injury, etc. A mortality predictive equation was calculated from univariate and multivariate logistic regression analyses in a set of randomly chosen participants and applied to a validation set of 35 participants.RESULTS:
The importance of each ion and protein for the equilibrium in the plasma charge is determinant. In statistical multivariate analysis, age, total body surface area burned, pH value, and [Mg(2+)] were independently associated with mortality.CONCLUSIONS:
[Na(+)], [HCO(3)(-)] (bicarbonate), and [Cl(-)] are the ions contributing the most to the plasma charge equilibrium in patients with major burns; a loss of 50% of plasma proteins in the first 48 hours is equivalent to the loss of 1 mmol/L of HCO(3)(-). Moreover, the consideration of plasma biochemical parameters in the first 48 hours may improve the mortality predictive equation of mortality for burned victims.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quemaduras
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Ann Plast Surg
Año:
2011
Tipo del documento:
Article
País de afiliación:
España