Bromopyridazinedione-mediated protein and peptide bioconjugation.
Chem Commun (Camb)
; 47(31): 8781-3, 2011 Aug 21.
Article
en En
| MEDLINE
| ID: mdl-21738916
ABSTRACT
Bromopyridazinedione-mediated bioconjugation to a cysteine containing protein and a disulfide containing peptide is described. The conjugates are cleavable in an excess of thiol, including cytoplasmically-relevant concentrations of glutathione, and show a high level of hydrolytic stability. The constructs have the potential for four points of chemical attachment.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptidos
/
Piridazinas
/
Proteínas
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Reino Unido